![]() ![]() The findings were further validated through ex-vivo testing on human skin biopsy. The in-vitro results on collagen and elastin were corroborated by up-regulation of COL1A, CO元B, fibronectin, and elastin gene expression from 3D human skin equivalents treated with the peel. The rationale behind this synergistic effect could be the conformational change in TCA from linear structure to ring-like structure, which was elucidated through sequential docking using Rosetta software. It was surprising to observe that trichloroacetic acid (TCA), which is considered a workhorse of chemical peels for its cauterant action, could synergistically promote the inhibitory action of lactic acid. In the in-vitro experiments, we found that the peel inhibits enzymes that are responsible for degradation of collagen and elastin, and the production of melanin pigment. ![]() In this research paper, we report our investigative findings to understand the mode of action of a commercial professional chemical peel to treat hyperpigmented and photoaged skin.
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